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MAML1 (Mastermind-like protein 1)
FEATURES
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FAMILY
DESCRIPTION
Also known as MAML1_HUMAN, MAML1, KIAA0200. Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8.Forms a complex with PRAG1, NOTCH1 and MAML1, in a MAML1-dependent manner (By similarity).
Also known as MAML1_HUMAN, MAML1, KIAA0200. Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylati ...
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MAML1

Mastermind-like protein 1

Expression

StudyTumor samplesMaxQ3Q2Q1MinNormal samplesMaxQ3Q2Q1MinLog2 (T vs N)
Adrenocortical (ACC) 77 2.33 2.12 2.06 1.98 1.80 126 2.31 2.06 2.02 1.96 -0.09 0.04
Bladder (BLCA) 406 2.24 1.97 1.90 1.83 1.50 9 2.13 2.09 2.05 1.95 1.93 -0.15
Breast (BRCA) 1067 2.41 2.01 1.96 1.91 1.46 178 2.17 2.02 1.98 1.95 1.78 -0.02
Cervical (CESC) 297 2.19 2.02 1.95 1.87 0.93 10 2.11 2.10 2.05 2.00 1.98 -0.09
Cholangiocarcinoma (CHOL) 36 2.03 1.95 1.89 1.83 1.70 0
Colon (COAD) 443 2.20 2.02 1.98 1.93 1.59 166 2.23 2.02 1.96 1.93 -0.09 0.02
B-cell lymphoma (DLBC) 42 2.06 1.96 1.83 1.69 1.55 337 2.72 2.37 2.25 2.14 1.73 -0.42
Esophageal (ESCA) 142 2.36 2.05 1.99 1.92 1.75 271 2.28 2.04 1.99 1.95 -0.09 -0.00
Glioblastoma (GBM) 160 2.18 1.84 1.78 1.72 1.29 214 2.55 2.17 2.14 2.10 -0.09 -0.36
Head and neck (HNSC) 432 2.30 2.03 1.96 1.88 1.27 55 2.06 1.98 1.97 1.93 1.84 -0.01