FEATURES

FAMILY

DESCRIPTION

Also known as EFNMT_MOUSE, EEF1AKNMT, Kiaa0859, Mettl13. Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2'. Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55'. Part of a tripartite complex containing GAB1, EEF1AKNMT and SPRY2. Interacts with GAB1. Interacts with SPRY2.

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EXTERNAL LINKS

EEF1AKNMT

eEF1A lysine and N-terminal methyltransferase

ligandability Mutations

EEF1AKNMT

Molecular Synopsis