FEATURES

DESCRIPTION

Also known as BAG2_MOUSE, Bag2. Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Binds to the ATPase domain of HSP/HSC70 chaperones. May interact with NWD1. Interacts with HSPA1A (via NBD), HSPA1B (via NBD) and HSPA8.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

Bag2

BAG family molecular chaperone regulator 2

ligandability Mutations

Bag2

Molecular Synopsis