FEATURES

FAMILY

DESCRIPTION

Also known as PAGP_SALTY, pagP. Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. Required for resistance to cationic antimicrobial peptides (CAMPs). Modifications of lipid A with a palmitate chain allow to evade host immune defenses by resisting antimicrobial peptides and attenuating the inflammatory response to infection triggered by lipopolysaccharide through the Toll-like receptor 4 (TLR4) signal transduction pathway. Homodimer.

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EXTERNAL LINKS

pagP

Lipid A palmitoyltransferase PagP

ligandability Mutations

pagP

Molecular Synopsis