FEATURES

DESCRIPTION

Also known as SSEI_SALTY, sseI, srfH. Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required to maintain a long-term chronic systemic infection in mice. It inhibits normal cell migration of primary macrophages and dendritic cells, by a mechanism that involves interaction with the host factor IQGAP1, an important regulator of the cytoskeleton and cell migration. Also accelerates the systemic spread of infection from the gastrointestinal tract to the bloodstream, probably by interacting with host TRIP6. Interacts with host IQGAP1 and host TRIP6 (thyroid receptor-interacting protein 6).

... More

EXTERNAL LINKS

sseI

Secreted effector protein SseI

ligandability Mutations

sseI

Molecular Synopsis