FEATURES

FAMILY

DESCRIPTION

Also known as UPPS_YERPE, uppS. Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E, 6E)-farnesyl diphosphate (E, E-FPP) to yield (2Z, 6Z, 10Z, 14Z, 18Z, 22Z, 26Z, 30Z, 34E, 38E)-undecaprenyl diphosphate (di-trans, octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. Homodimer.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

uppS

Ditrans, polycis-undecaprenyl-diphosphate synthase ((2E, 6E)-farnesyl-diphosphate specific)

ligandability Mutations

uppS

Molecular Synopsis