FEATURES

FAMILY

DESCRIPTION

Also known as ISPF_SALTI, ispF. Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). Homotrimer.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

ispF

2-C-methyl-D-erythritol 2, 4-cyclodiphosphate synthase

ligandability Mutations

ispF

Molecular Synopsis