FEATURES

FAMILY

DESCRIPTION

Also known as IXTPA_SALTI, rdgB, yggV. Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Homodimer.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

rdgB

dITP/XTP pyrophosphatase

ligandability Mutations

rdgB

Molecular Synopsis