FEATURES

FAMILY

DESCRIPTION

Also known as FABH_RALSO, fabH. Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids. Homodimer.

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EXTERNAL LINKS

fabH

3-oxoacyl-[acyl-carrier-protein] synthase 3

ligandability Mutations

fabH

Molecular Synopsis