FEATURES

FAMILY

DESCRIPTION

Also known as GLYA_CLOPE, glyA. Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Homodimer.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

glyA

Serine hydroxymethyltransferase

ligandability Mutations

glyA

Molecular Synopsis