FEATURES

FAMILY

DESCRIPTION

Also known as MUG_ECO57, mug. Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells. Binds DNA as a monomer.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

mug

G/U mismatch-specific DNA glycosylase

ligandability Mutations

mug

Molecular Synopsis