FEATURES

FAMILY

DESCRIPTION

Also known as LTO1_HUMAN, LTO1, ORAOV1, TAOS1. The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:23318452). May play a role in the regulation of proline metabolism and ROS production (PubMed:24930674). Forms a complex with YAE1 (PubMed:23318452). Interacts with PYCR1 and PYCR2 (PubMed:24930674).

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EXTERNAL LINKS

LTO1

Protein LTO1 homolog

ligandability Mutations

LTO1

Molecular Synopsis