FEATURES

FAMILY

DESCRIPTION

Also known as ITPR2_BOVIN, ITPR2. Receptor for inositol 1, 4, 5-trisphosphate, a second messenger that mediates the release of intracellular calcium (PubMed:11584008). This release is regulated by cAMP both dependently and independently of PKA (By similarity). Homotetramer. Interacts with CABP1. Interacts with BOK; regulates ITPR2 expression. Interacts with BCL2L10 (By similarity). Interacts with TRPC4 (By similarity).

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

ITPR2

Inositol 1, 4, 5-trisphosphate receptor type 2

ligandability Mutations

ITPR2

Molecular Synopsis