FEATURES

FAMILY

DESCRIPTION

Also known as GENL2_ORYSJ, SEND1, GEN2. Single-stranded DNA endonuclease activity in vitro (PubMed:12602891). May not be active as double-stranded DNA endonuclease (PubMed:12602891). Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA with a specific cleavage site in the 5' overhang strand exactly one nucleotide 3' of the branch point (By similarity). Structure- and sequence-specific nuclease that resolves holliday junctions (HJs) by symmetrically oriented incisions in two opposing strands near the junction point, thus leading to ligatable products; HJs are physical links between homologous DNA molecules that arise as central intermediary structures during homologous recombination and repair in meiotic and somatic cells (By similarity). Probably involved in the resolution of toxic replication structures to ensure genome stability, and to maintain telomere integrity and replication (By similarity).

... More

EXTERNAL LINKS

SEND1

Single-strand DNA endonuclease 1

ligandability Mutations

SEND1

Molecular Synopsis