FEATURES

FAMILY

protein prenyltransferase subunit alpha family

DESCRIPTION

Also known as PGTA1_ARATH, RGTA1. Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -CCXX, CXXX, -XCCX and -XCXC, such as RABA1A, RABA2A, RABF2A and RABG2 (PubMed:26589801). In vitro, can prenylate PGGTI targets with the C-terminal Cys-aliphatic-aliphatic-X (CaaX) with leucine in the terminal position. Substrates with the C-terminal sequence -CSIL such as ARAC11/ROP1 or GG2/AGG2 are prenylated independently of REP and when the alpha subunit is associated with a beta subunit (RGTB1 or RGTB2) (PubMed:26589801). Heterotrimer composed of the alpha subunit RGTA, the beta subunit RGTB and REP; within this trimer, RGTA and RGTB form the catalytic component, while REP mediates peptide substrate binding.

... More

EXTERNAL LINKS

RGTA1

Geranylgeranyl transferase type-2 subunit alpha 1

ligandability Mutations

RGTA1

Molecular Synopsis