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AGR3 (Anterior gradient protein 3)
FEATURES
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FAMILY
DESCRIPTION
Also known as AGR3_HUMAN, AGR3, BCMP11, PDIA18. Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells. Interacts with LYPD3 and DAG1 (alphaDAG1).
Also known as AGR3_HUMAN, AGR3, BCMP11, PDIA18. Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells. Interacts with LYPD3 and DAG1 (alphaDAG1).
AGR3 logo

AGR3

Anterior gradient protein 3

Germline Genetics

Summary of germline evidence for AGR3 and cancer

  • Ensembl Gene ID: ENSG00000173467
  • Ensembl Transcript ID/s: ENST00000310398
  • Entrez Gene ID: 155465
  • HGNC Gene Symbol: AGR3

Genome-wide association studies

AGR3 maps to cancer-SNP associations according to the following annotations:

SNPLocusPosition (b37)Risk alleleRAFP-valueEffect sizeCICancerPMIDCatalogTADLSDEPICT
1751_rs117132860 7p21.1 17134708 rs117132860-A 0.02 4E-8 1.48 Cutaneous squamous cell carcinoma 27424798 https://www.ebi.ac.uk/gwas/search?query=rs117132860 7:16820000-17700000 r2>0.3 (7:16791775-17250993) -
1677_rs1636744 7p21.1 16984280 rs1636744-T 0.4 7E-9 0.091 [NR] unit increase Cutaneous malignant melanoma 26237428 https://www.ebi.ac.uk/gwas/search?query=rs1636744 7:16820000-17700000 r2>0.3 (7:16920861-17081168) YES
1185_rs1636744 7p21.1 16984280 rs1636744-T 0.41 7E-9 1.1 [NR] Melanoma 28212542 https://www.ebi.ac.uk/gwas/search?query=rs1636744 7:16820000-17700000 r2>0.3 (7:16920861-17081168) YES