FEATURES

FAMILY

DESCRIPTION

Also known as NEK11_HUMAN, NEK11. Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. Interacts with isoform 1 of NEK2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NEK11

Serine/threonine-protein kinase Nek11

NEK11

Molecular Synopsis