FEATURES

FAMILY

DESCRIPTION

Also known as IPMK_HUMAN, IPMK, IMPK. Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1, 4, 5-trisphosphate (Ins(1, 4, 5)P3) first to inositol 1, 3, 4, 5-tetrakisphosphate and then to inositol 1, 3, 4, 5, 6-pentakisphosphate (Ins(1, 3, 4, 5, 6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1, 3, 4, 6-tetrakisphosphate (Ins(1, 3, 4, 6)P4) (PubMed:12223481). Phosphorylates glycero-3-phospho-1D-myo-inositol 4, 5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3, 4, 5-trisphosphate (PubMed:30420721, PubMed:28882892). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1, 3, 4, 5, 6-pentakisphosphate (Ins(1, 3, 4, 5, 6)P5) and inositol hexakisphosphate (InsP6) (By similarity).

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EXTERNAL LINKS

IPMK

Inositol polyphosphate multikinase

ligandability Mutations

IPMK

Molecular Synopsis