FEATURES

FAMILY

DESCRIPTION

Also known as TRPV3_HUMAN, TRPV3. Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). May form a heteromeric channel with TRPV1. Interacts with TRPV1.

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EXTERNAL LINKS

TRPV3

Transient receptor potential cation channel subfamily V member 3

ligandability Mutations

TRPV3

Molecular Synopsis