FEATURES

FAMILY

class V-like SAM-binding methyltransferase superfamily

DESCRIPTION

Also known as SMYD1_HUMAN, SMYD1. Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis. Interacts with HDAC1, HDAC2 and HDAC3. Interacts (via MYND-type zinc finger) with NACA isoform skNAC.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SMYD1

Histone-lysine N-methyltransferase SMYD1

SMYD1

Molecular Synopsis