FEATURES

FAMILY

NAD-dependent glycerol-3-phosphate dehydrogenase family

DESCRIPTION

Also known as GPD1L_HUMAN, GPD1L, KIAA0089. Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. Interacts with SCN5A.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GPD1L

Glycerol-3-phosphate dehydrogenase 1-like protein

GPD1L

Molecular Synopsis