BU52_01220 ((3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase)

FEATURES

FAMILY

DESCRIPTION

Also known as DPGC_STRTO, BU52_01220. Involved in the biosynthesis of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. Catalyzes the unusual conversion 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) to 3,5-dihydroxyphenylglyoxylate. DpgC performed a net four-electron oxidation of the benzylic carbon of DPA-CoA and the hydrolysis of the thioester bond to generate free CoA (PubMed:18004875, PubMed:17507985). DpgC has the ability to process a diverse range of substituted phenylacetyl-CoA substrates (PubMed:18004875). Homohexamer; dimer of trimers.

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EXTERNAL LINKS

BU52_01220

(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

BU52_01220

Molecular Synopsis