FEATURES

FAMILY

DESCRIPTION

Also known as KCC1D_HUMAN, CAMK1D, CAMKID. Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.

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EXTERNAL LINKS

CAMK1D

Calcium/calmodulin-dependent protein kinase type 1D

ligandability Mutations

CAMK1D

Molecular Synopsis