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CAMK1D (Calcium/calmodulin-dependent protein kinase type 1D)
FEATURES
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FAMILY
DESCRIPTION
Also known as KCC1D_HUMAN, CAMK1D, CAMKID. Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.
Also known as KCC1D_HUMAN, CAMK1D, CAMKID. Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal ne ...
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CAMK1D

Calcium/calmodulin-dependent protein kinase type 1D

Copy number variation

DiseaseSignal Cell linesGain Cell linesAvg. ampLoss Cell linesAvg. lossNo-signal Cell linesAvg. change
cancer 3 2 1.88 1 0.47 144 1.00
NS 3 1 1.89 2 0.39 150 0.98
carcinoma 7 3 1.89 4 0.39 545 0.95
haematopoietic_neoplasm 0 0 0 63 0.98
leukaemia 0 0 0 83 0.97
lymphoid_neoplasm 0 0 0 133 0.97
glioma 1 0 1 0.47 51 0.81
malignant_melanoma 0 0 0 56 0.76
melanoma 0 0 0 43 0.75
glioblastoma 0 0 0 2 1.11

Cell lines

Cell lineSignalCopy numberAvg. genome ploidyAmplificationDiseaseTissue
22Rv-1 No signal 2 2.04 0.98 cancer, NS, carcinoma prostate
5637 No signal 2 2.99 0.67 cancer, carcinoma bladder, urinary_tract
639-V No signal 3 2.41 1.25 cancer, carcinoma bladder, ureter, urinary_tract
647-V No signal 2 2.50 0.80 cancer, carcinoma bladder, urinary_tract
697 No signal 2 1.98 1.01 haematopoietic_neoplasm, leukaemia, lymphoid_neoplasm blood_bone_marrow, haematopoietic_and_lymphoid_tissue
769-P No signal 2 1.97 1.02 carcinoma kidney
786-0 No signal 4 3.82 1.05 cancer, carcinoma kidney
8-MG-BA No signal 2 2.20 0.91 glioma brain, central_nervous_system
8305C No signal 3 3.09 0.97 carcinoma thyroid
8505C No signal 2 3.00 0.67 carcinoma thyroid