mtnP (S-methyl-5'-thioadenosine phosphorylase)

FEATURES

FAMILY

DESCRIPTION

Also known as MTAP_THEEB, mtnP. Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. Homohexamer. Dimer of a homotrimer.

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EXTERNAL LINKS

mtnP

S-methyl-5'-thioadenosine phosphorylase

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

mtnP

Molecular Synopsis