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BPHL (Valacyclovir hydrolase)
FEATURES
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FAMILY
DESCRIPTION
Also known as BPHL_HUMAN, BPHL, MCNAA. Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Monomer. May also form homodimers.
Also known as BPHL_HUMAN, BPHL, MCNAA. Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophob ...
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BPHL

Valacyclovir hydrolase

Germline Genetics

Summary of germline evidence for BPHL and cancer

  • Ensembl Gene ID: ENSG00000137274
  • Ensembl Transcript ID/s: ENST00000380375; ENST00000380379; ENST00000434640
  • Entrez Gene ID: 670
  • HGNC Gene Symbol: BPHL

Genome-wide association studies

BPHL maps to cancer-SNP associations according to the following annotations:

SNPLocusPosition (b37)Risk alleleRAFP-valueEffect sizeCICancerPMIDCatalogTADLSDEPICT
1095_rs73718779 6p25.2 2969278 rs73718779-A 0.11 2E-8 1.26 [1.16-1.36] Chronic lymphocytic leukemia 26956414 https://www.ebi.ac.uk/gwas/search?query=rs73718779 6:2860000-4100000 r2>0.9 (6:2535380-3460467) -