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BPHL (Valacyclovir hydrolase)
FEATURES
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FAMILY
DESCRIPTION
Also known as BPHL_HUMAN, BPHL, MCNAA. Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Monomer. May also form homodimers.
Also known as BPHL_HUMAN, BPHL, MCNAA. Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophob ...
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BPHL

Valacyclovir hydrolase

Expression

StudyTumor samplesMaxQ3Q2Q1MinNormal samplesMaxQ3Q2Q1MinLog2 (T vs N)
Adrenocortical (ACC) 77 1.86 1.56 1.51 1.42 1.01 126 1.83 1.66 1.61 1.56 -0.09 -0.10
Bladder (BLCA) 406 2.12 1.63 1.52 1.39 1.02 9 1.70 1.62 1.56 1.51 1.34 -0.05
Breast (BRCA) 1067 1.99 1.64 1.55 1.46 0.99 178 2.11 1.69 1.58 1.51 1.07 -0.03
Cervical (CESC) 297 1.88 1.55 1.44 1.34 1.01 10 1.66 1.65 1.60 1.54 1.34 -0.16
Cholangiocarcinoma (CHOL) 36 2.04 1.82 1.66 1.50 1.19 0
Colon (COAD) 443 2.00 1.64 1.56 1.46 0.95 166 1.80 1.59 1.50 1.41 -0.09 0.06
B-cell lymphoma (DLBC) 42 1.85 1.43 1.26 1.20 0.94 337 1.98 1.07 0.96 0.83 -0.46 0.30
Esophageal (ESCA) 142 1.69 1.42 1.31 1.18 0.88 271 1.72 1.58 1.54 1.49 -0.09 -0.23
Glioblastoma (GBM) 160 1.96 1.55 1.47 1.43 1.14 214 1.76 1.60 1.55 1.50 -0.09 -0.08
Head and neck (HNSC) 432 1.84 1.47 1.39 1.31 0.91 55 1.67 1.59 1.53 1.50 1.34 -0.14