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BPHL (Valacyclovir hydrolase)
FEATURES
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FAMILY
DESCRIPTION
Also known as BPHL_HUMAN, BPHL, MCNAA. Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Monomer. May also form homodimers.
Also known as BPHL_HUMAN, BPHL, MCNAA. Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophob ...
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BPHL

Valacyclovir hydrolase

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