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ORF2 (Secreted protein ORF2)
FEATURES
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FAMILY
DESCRIPTION
Also known as CAPSD_HEVCH, ORF2. Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry., Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other (By similarity). Binds to the 5' end of the genomic RNA to mediate genome encapsidation (By similarity). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry (PubMed:19812150). Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (PubMed:27155063). Isoform Secreted protein ORF2: Homodimers (PubMed:29669922). Isoform Capsid protein ORF2: Self-assembles to form the capsid. The capsid is dominated by dimers that define the 30 morphological units. Interacts with phosphorylated protein ORF3 (By similarity). Interacts with host TMEM134 (PubMed:27899274). Interacts with host ASGR1 and ASGR2; these interactions facilitate infection of host hepatocytes (PubMed:27155063).
Also known as CAPSD_HEVCH, ORF2. Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry., Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other (By similarity). Binds to the 5' end of the genomic RNA to mediate genome encapsid ...
ORF2 logo

ORF2

Secreted protein ORF2

Molecular Synopsis