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mib1 (E3 ubiquitin-protein ligase mib1)
FEATURES
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DESCRIPTION
Also known as MIB1_DANRE, mib1, mib. E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intestine. Essential for early embryonic development. Interacts with deltaA (dla) and deltaD (dld).
Also known as MIB1_DANRE, mib1, mib. E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes re ... More
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mib1

E3 ubiquitin-protein ligase mib1

Molecular Synopsis