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HUB1 (E3 ubiquitin-protein ligase BRE1-like 1)
FEATURES
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FAMILY
DESCRIPTION
Also known as BRE1A_ORYSJ, HUB1, BRE1A. E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is a prerequisite for H3 Lys-4 methylation (H3K4me). It thereby plays a central role in histone code and gene regulation. H2B monoubiquitination (H2BK143ub1), mediated by HUB1, modulates transcriptional regulation of anther development, likely by promoting histone H3K4 dimethylation (H3K4me2) in the chromatin of the key tapetum degradation-related genes C4, CP1 and UDT1. Interacts with SKIPA (PubMed:19339499). Interacts with HUB2 (PubMed:26143250).
Also known as BRE1A_ORYSJ, HUB1, BRE1A. E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is a prerequisite for H3 Lys-4 methylation (H3K4me). It thereby plays a central role in histone code and gene regulation. H2B monoubiquitination (H2BK143ub1) ... More
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HUB1

E3 ubiquitin-protein ligase BRE1-like 1

Molecular Synopsis