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glyA1 (Serine hydroxymethyltransferase 1)
FEATURES
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FAMILY
DESCRIPTION
Also known as GLYA1_BORBR, glyA1. Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Homodimer.
Also known as GLYA1_BORBR, glyA1. Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independe ... More
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glyA1

Serine hydroxymethyltransferase 1

Molecular Synopsis