FEATURES

FAMILY

DESCRIPTION

Also known as RHOU_HUMAN, RHOU, ARHU, CDC42L1, G28K, WRCH1. Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Interacts with PAK3. Interacts with ARHGAP30 in a GTP-independent manner. In its GTP-loaded conformation, interacts with ARHGAP31. Interacts with PTK2B/PYK2.

Also known as RHOU_HUMAN, RHOU, ARHU, CDC42L1, G28K, WRCH1. Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RHOU

Mutations

Mutation(s) distribution

Mutations table