FEATURES

FAMILY

DESCRIPTION

Also known as NEK10_HUMAN, NEK10. Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport (PubMed:31959991). Interacts with RAF1 and MAP2K1; the interaction is direct with RAF1 and required for ERK1/2-signaling pathway activation in response to UV irradiation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NEK10

Serine/threonine-protein kinase Nek10

NEK10

Molecular Synopsis