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PAQR6 (Membrane progestin receptor delta)
FEATURES
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FAMILY
DESCRIPTION
Also known as PAQR6_HUMAN, PAQR6. Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23763432, PubMed:23161870). Homodimer.
Also known as PAQR6_HUMAN, PAQR6. Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:2376 ...
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PAQR6

Membrane progestin receptor delta

Copy number variation

DiseaseSignal Cell linesGain Cell linesAvg. ampLoss Cell linesAvg. lossNo-signal Cell linesAvg. change
cancer 1 1 1.86 0 146 1.15
NS 0 0 0 153 1.15
carcinoma 4 4 2.16 0 548 1.15
haematopoietic_neoplasm 0 0 0 63 1.12
leukaemia 0 0 0 84 1.09
lymphoid_neoplasm 0 0 0 135 1.15
glioma 0 0 0 52 1.07
malignant_melanoma 0 0 0 56 1.14
melanoma 0 0 0 43 1.12
glioblastoma 0 0 0 2 1.40

Cell lines

Cell lineSignalCopy numberAvg. genome ploidyAmplificationDiseaseTissue
22Rv-1 No signal 3 2.04 1.47 cancer, NS, carcinoma prostate
5637 No signal 3 2.99 1.00 cancer, carcinoma bladder, urinary_tract
639-V No signal 2 2.41 0.83 cancer, carcinoma bladder, ureter, urinary_tract
647-V No signal 4 2.50 1.60 cancer, carcinoma bladder, urinary_tract
697 No signal 2 1.98 1.01 haematopoietic_neoplasm, leukaemia, lymphoid_neoplasm blood_bone_marrow, haematopoietic_and_lymphoid_tissue
769-P No signal 2 1.97 1.02 carcinoma kidney
786-0 No signal 4 3.82 1.05 cancer, carcinoma kidney
8-MG-BA No signal 2 2.20 0.91 glioma brain, central_nervous_system
8305C No signal 2 3.09 0.65 carcinoma thyroid
8505C No signal 3 3.00 1.00 carcinoma thyroid