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NOP10 (H/ACA ribonucleoprotein complex subunit NOP10)
FEATURES
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FAMILY
DESCRIPTION
Also known as NOP10_YEAST, NOP10. Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:9843512). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:9843512). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (PubMed:9843512). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909). The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA (PubMed:21131909). Essential for growth (PubMed:9843512). Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) (PubMed:9843512, PubMed:21131909). The protein component of the H/ACA snoRNP contains CBF5, GAR1, NHP2 and NOP10 (PubMed:9843512, PubMed:21131909). The complex contains a stable core composed of CBF5 and NOP10, to which GAR1 and NHP2 subsequently bind (PubMed:9843512).
Also known as NOP10_YEAST, NOP10. Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:9843512). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed: ...
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NOP10

H/ACA ribonucleoprotein complex subunit NOP10

Molecular Synopsis