FEATURES

FAMILY

DESCRIPTION

Also known as NCEH1_HUMAN, NCEH1, AADACL1, KIAA1363. Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:17052608). May be responsible for cholesterol ester hydrolysis in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). May contribute to cancer pathogenesis by promoting tumor cell migration (PubMed:17052608).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NCEH1

Neutral cholesterol ester hydrolase 1

NCEH1

Molecular Synopsis