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ULK3 (Serine/threonine-protein kinase ULK3)
FEATURES
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FAMILY
DESCRIPTION
Also known as ULK3_HUMAN, ULK3. Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. Interacts (via protein kinase domain) with SUFU.
Also known as ULK3_HUMAN, ULK3. Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or ...
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ULK3

Serine/threonine-protein kinase ULK3

Molecular Synopsis

LIGANDABILITY
APPROVED DRUGS
No approved drugs found
INVESTIGATIONAL DRUGS
No investigational drugs found
CHEMICAL PROBES
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NETWORK-BASED
CANCER SCORE
No score found
OTHER DISEASES SCORE
No score found
CHEMISTRY-BASED
CHEMISTRY-BASED SCORE