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Kmt2d (Histone-lysine N-methyltransferase 2D)
FEATURES
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FAMILY
DESCRIPTION
Also known as KMT2D_MOUSE, Kmt2d, Mll2, Mll4. Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. Interacts with ESR1; interaction is direct (By similarity). Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (PubMed:21335234). Interacts (via WIN motif) with WDR5 (By similarity).
Also known as KMT2D_MOUSE, Kmt2d, Mll2, Mll4. Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. Interacts with ESR1; interaction is direct (By simil ...
Kmt2d logo

Kmt2d

Histone-lysine N-methyltransferase 2D

Molecular Synopsis