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Usp49 (Ubiquitin carboxyl-terminal hydrolase 49)
FEATURES
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FAMILY
DESCRIPTION
Also known as UBP49_MOUSE, Usp49. Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Component of a complex with RUVBL1 and PSMC5.
Also known as UBP49_MOUSE, Usp49. Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons (By similarity). Component of a complex wit ...
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Usp49

Ubiquitin carboxyl-terminal hydrolase 49

Molecular Synopsis