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Primpol (DNA-directed primase/polymerase protein)
FEATURES
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FAMILY
DESCRIPTION
Also known as PRIPO_MOUSE, Primpol, Ccdc111. DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH (By similarity). Interacts with RPA1.
Also known as PRIPO_MOUSE, Primpol, Ccdc111. DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage- ...
Primpol logo

Primpol

DNA-directed primase/polymerase protein

Molecular Synopsis