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H3F3C (Histone H3.3C)
FEATURES
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FAMILY
DESCRIPTION
Also known as H3C_HUMAN, H3F3C. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Also known as H3C_HUMAN, H3F3C. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated ...
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H3F3C

Histone H3.3C

Germline Genetics

Summary of germline evidence for H3F3C and cancer

  • Ensembl Gene ID: ENSG00000188375
  • Ensembl Transcript ID/s: ENST00000340398
  • Entrez Gene ID: 440093
  • HGNC Gene Symbol: H3F3C

Genome-wide association studies

H3F3C maps to cancer-SNP associations according to the following annotations:

SNPLocusPosition (b37)Risk alleleRAFP-valueEffect sizeCICancerPMIDCatalogTADLSDEPICT
163_rs4931000 12p11.21 32141495 rs4931000-G 0.22 2E-11 1.16 [1.11-1.22] Testicular germ cell tumor 28604728 https://www.ebi.ac.uk/gwas/search?query=rs4931000 12:31380000-32900000 r2>0.1 (12:31879902-32530257) -