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H3F3C (Histone H3.3C)
FEATURES
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FAMILY
DESCRIPTION
Also known as H3C_HUMAN, H3F3C. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Also known as H3C_HUMAN, H3F3C. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated ...
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H3F3C

Histone H3.3C

Copy number variation

DiseaseSignal Cell linesGain Cell linesAvg. ampLoss Cell linesAvg. lossNo-signal Cell linesAvg. change
cancer 5 3 2.18 2 0.44 142 1.10
NS 2 1 3.27 1 0.48 151 1.08
carcinoma 16 14 2.50 2 0.44 536 1.12
haematopoietic_neoplasm 0 0 0 63 1.02
leukaemia 0 0 0 84 1.03
lymphoid_neoplasm 0 0 0 135 1.05
glioma 0 0 0 52 0.99
malignant_melanoma 0 0 0 56 1.07
melanoma 0 0 0 43 1.09
glioblastoma 0 0 0 2 0.97

Cell lines

Cell lineSignalCopy numberAvg. genome ploidyAmplificationDiseaseTissue
22Rv-1 No signal 3 2.04 1.47 cancer, NS, carcinoma prostate
5637 No signal 3 2.99 1.00 cancer, carcinoma bladder, urinary_tract
639-V No signal 2 2.41 0.83 cancer, carcinoma bladder, ureter, urinary_tract
647-V No signal 3 2.50 1.20 cancer, carcinoma bladder, urinary_tract
697 No signal 2 1.98 1.01 haematopoietic_neoplasm, leukaemia, lymphoid_neoplasm blood_bone_marrow, haematopoietic_and_lymphoid_tissue
769-P No signal 2 1.97 1.02 carcinoma kidney
786-0 No signal 4 3.82 1.05 cancer, carcinoma kidney
8-MG-BA No signal 2 2.20 0.91 glioma brain, central_nervous_system
8305C No signal 4 3.09 1.29 carcinoma thyroid
8505C No signal 3 3.00 1.00 carcinoma thyroid