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RINT1 (RAD50-interacting protein 1)
FEATURES
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FAMILY
DESCRIPTION
Also known as RINT1_HUMAN, RINT1. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control (PubMed:11096100). Essential for telomere length control (PubMed:16600870). Component of the NRZ complex composed of NBAS, ZW10 and RINT1/TIP20L; NRZ associates with SNAREs STX18, USE1L, BNIP1/SEC20L and SEC22B (the assembly has been described as syntaxin 18 complex) (PubMed:15029241, PubMed:20462495, PubMed:19369418). Interacts directly with BNIP1/SEC20L and ZW10 (PubMed:15029241, PubMed:15272311). Interacts with UVRAG (PubMed:24056303). Interacts with RAD50 during late S and G2/M phases (PubMed:11096100). Interacts with RBL2, preferentially with the active, hypophosphorylated form (PubMed:16600870).
Also known as RINT1_HUMAN, RINT1. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control (PubMed:11096100). Essential for te ...
RINT1 logo

RINT1

RAD50-interacting protein 1

Molecular Synopsis