Hsd17b8 (Estradiol 17-beta-dehydrogenase 8)

FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as DHB8_RAT, Hsd17b8. NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.

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EXTERNAL LINKS

Hsd17b8

Estradiol 17-beta-dehydrogenase 8

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

Hsd17b8

Molecular Synopsis