FEATURES

FAMILY

DESCRIPTION

Also known as KDM4D_HUMAN, KDM4D, JHDM3D, JMJD2D. Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

KDM4D

Lysine-specific demethylase 4D

ligandability Mutations

KDM4D

Molecular Synopsis