Dnajb6 (DnaJ homolog subfamily B member 6)

FEATURES

DESCRIPTION

Also known as DNJB6_RAT, Dnajb6. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). Homooligomer. Interacts with BAG3, HSPB8 and STUB1. Interacts with HSP70, KRT18 and PTTG. Interacts with ALKBH1.

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EXTERNAL LINKS

Dnajb6

DnaJ homolog subfamily B member 6

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

Dnajb6

Molecular Synopsis