Pxn logo
Pxn (Paxillin)
FEATURES
Loading...
Loading...
FAMILY
DESCRIPTION
Also known as PAXI_RAT, Pxn. Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Binds to vinculin and to the SH3 domain of SRC. Interacts with GIT1 and NUDT16L1/SDOS. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds ASAP2 and PDCD10 (By similarity). Interacts with PARVA, PARVB, SORBS1 and TGFB1I1. Interacts with NEK3 and this interaction is prolactin-dependent (By similarity). Interacts with PTK2/FAK1 and PTK2B/PYK2 (By similarity). Interacts with PTK6 (By similarity). Interacts with CD36. Interacts (via cytoplasmic domain) with CEACAM1; the interaction is phosphotyrosyl-dependent (By similarity). Interacts with PXN; this complex stabilizes actin dynamics (By similarity).
Also known as PAXI_RAT, Pxn. Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Binds to vinculin and to the SH3 domain of SRC. Interacts with GIT1 and NUDT16L1/SDOS. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds ASAP2 and PDCD10 ( ... More
Pxn logo

Pxn

Paxillin

Molecular Synopsis