Prdm2 (PR domain zinc finger protein 2)

FEATURES

FAMILY

class V-like SAM-binding methyltransferase superfamily

DESCRIPTION

Also known as PRDM2_RAT, Prdm2, Riz. S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene (By similarity). Binds to the retinoblastoma protein (RB). Interacts with GATA3 (By similarity).

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EXTERNAL LINKS

Prdm2

PR domain zinc finger protein 2

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

Prdm2

Molecular Synopsis