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LIN9 (Protein lin-9 homolog)
FEATURES
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FAMILY
DESCRIPTION
Also known as LIN9_HUMAN, LIN9, BARA, TGS. Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RB1.
Also known as LIN9_HUMAN, LIN9, BARA, TGS. Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F ...
LIN9 logo

LIN9

Protein lin-9 homolog

Interactome

LIN9 is reported in 7 pathways.
Provide LogoProviderPathway sizePathway name
Activation of E2F1 target genes at G1/S logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 29 Activation of E2F1 target genes at G1/S
Cyclin A:Cdk2-associated events at S phase entry logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 30 Cyclin A:Cdk2-associated events at S phase entry
Cyclin E associated events during G1/S transition logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 28 Cyclin E associated events during G1/S transition
G0 and Early G1 logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 18 G0 and Early G1
Polo-like kinase mediated events logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 16 Polo-like kinase mediated events
Transcription of E2F targets under negative control by DREAM complex logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 19 Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 16 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1